After her studies of literature and art history at the École Normale Supérieure in her hometown Paris, Mariame Clément lived in the U.S.A. and in Berlin, where she did her first internships at the Staatsoper Unter den Linden.

She made her directing debut in 2004 with Rossini's Il Signor Bruschino and Puccini's Gianni Schicchi in Lausanne. She has worked in Athens (Le Comte Ory), Tel Aviv (Il Viaggio a Reims), Santiago de Chile (Lulu), Oviedo (Il Barbiere di Siviglia), Sevilla (Agrippina), Nuremberg (Le Nozze di Figaro), Essen (Le Grand Macabre, Salome), Strasbourg (La Belle Hélène, Werther, Platée, Der Rosenkavalier, La Calisto), Antwerp/Ghent (Giasone, Agrippina, Armida), Graz (Faust, Die Zauberflöte), at the Theater an der Wien (Castor et Pollux, The Fairy Queen), in Glyndebourne (Don Pasquale, Poliuto, Il Turco in Italia, Don Giovanni), at the Opéra national de Paris (Hänsel und Gretel, Cendrillon), at the Royal Opera House (L'Étoile), at the Théâtre des Champs-Élysées (Il Ritorno d'Ulisse in patria), at the Semperoper Dresden (Die verkaufte Braut), at the Bregenz Festival (Don Quichotte), at the Santa Fe Opera (Carmen), and at the Volksoper in Vienna (Die Lustige Witwe).

In 2014 she created Philippe Hurel's opera, Les Pigeons d'argile, at the Théâtre du Capitole in Toulouse. In 2016, she staged the French premiere of Wagner's second opera, Das Liebesverbot, at the Opéra national du Rhin. Her production of Barkouf in the same theatre in 2018 was the first performance since 1860 of this newly rediscovered major piece by Offenbach.

With Roberto Devereux in June 2024, she completed a Donizetti trilogy at the Grand Théâtre de Genève which began with Anna Bolena in 2021 and continued with Maria Stuarda in 2022.

She made her debut at the Salzburg Festival in the summer of 2024 with Les Contes d'Hoffmann.

Further projects will take her, among other places, to Berlin, Copenhagen and Glyndebourne.